When the bed first arrives, remove all packaging immediately and allow the mattress to breath for a few hours before placing any bedding on it.  Moisture can build up when a mattress is in it's wrapping, so airing it, will help the moisture evaporate. 

Air the bed by throwing back the bed sheets for half an hour before you remake it.

Turn the mattress every week for the first month, then turn it once every two to three months.  This will allow the upholstery to settle evenly.  It should also be turned occasionally from head to foot

Vacuum the mattress carefully, but not on the full setting, as this may dislodge the fillings.

If you are an asthma or allergy sufferer, place washable barrier sheets on the mattress.  If you have a latex mattress this may not be necessary.

Never roll a sprung mattress, this could damage the springs